Omics data types
The suffix ‘ome’ refers to a totality of some (molecular biological) sort. The suffix ‘omics’ then refers to the collective quantification of some pool of molecular molecules. In our group we consider a wide variety of omics data. Genomics alludes to the omics of the genome (DNA, DNA-methylation, RNA, micro-RNA) while metabolomics implies the omics of small-molecule metabolites (i.e., the products of metabolism). Microbiomics refers to the genomics of microorganisms living in the gastrointestinal tract. As a group we are involved in the statistical support of studies on the genomics of cancer, the metabolomics of neurodegenerative disease, and the microbiomics of irritable bowel syndrome.
Many of us started working with genomics data produced by microarrays, such as DNA copy number, RNA expression and even DNA methylation and microRNA expression. We have vast experience in both pre-processing and analysis of such data. Currently, most genomic profiles are obtained via next-generation sequencing (NGS). Pre-processing and analysis of omics profiles produced by NGS are performed routinely by our group, including that of DNA copy number and methylation, RNAseq and microRNAseq. We also regularly handle (whole genome) RNA-interference screens data, again from pre-processing to analysis. In addition, we have expertise in various platforms for metabolomics and microbiomics.